Centrophenoxine is one of the first nootropics. Developed in the late 50′s it has been used to treat a wide variety of mental problems.



  • Increases overall intelligence and many cognitive functions including language understanding, problem solving, and decision making [2][3]
  • Improves consolidation of long term memory [1]
  • Increased mental alertness [1][4]
  • Positive effect on mood [4]
  • Increase lifespan and anti-aging effects [2]
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What Is Centrophenoxine?

Centrophenoxiner is older nootropic developed in 1959 at the French Scientific Research Center. Since its development is has been the subject of many studies and is commonly used to treat symptoms of senile dementia and Alzheimer’s disease.

Centrophenoxine Dosage Information

For those taking Centrophenoxine for its nootropic benefits a dosage of 250mg taken once or twice per day is recommended.

Dosages that have been used in the majority of human studies consisted of 300-1000mg taken two times a day. Doses were usually taken at breakfast and lunch. [2] These higher doses are taken as a treatment to psychological and neurological diseases.

How Does Centrophenoxine Work?

Centrophenoxine is created by reacting DMAE (an organic compound found in nature) with pCPA (a synthetic compound similar to chemicals in a group of plant hormones called auxins).  After consumption, some of  Centrophenoxine is broken down into these two precursors.

The liver then converts the DMAE to choline which has its own range of nootropic properties. As this is happening, the remaining Centrophenoxine circulates throughout the body, eventually entering the brain and heart. Once it reaches the brain even more Centrophenoxine is broken down allowing DMAE to enter your brain. Any DMAE released before Centrophenoxine enters your brain cannot cross the blood-brain barrier. pCPA can cross the blood-brain barrier much more easily meaning the brain gets pCPA broken down from Centrophenoxine at any time. Both of these compounds reaching your brain cause a number of nootropic benefits.  [2]

Safety and Side Effects of Centrophenoxine

Centrophenoxine is considered very safe. Reported side effects include upset stomach, mild dizziness, headaches, and insomnia. At higher doses jaw clenching may occur. If any of these side effects occur you should discontinue use or lower your dosage. Taking a dose every other day has also been shown to eliminate side effects.

People who suffer from high blood pressure or certain convulsive disorders such as epilepsy should avoid taking Centrophenoxine. Pregnant women should also avoid Centrophenoxine. [2]


Centrophenoxine FAQ

Below are some of the most commonly asked questions about Centrophenoxine. If you have a question that’s not on this list, send it to us at questions@whatarenootropics.com and we will answer it for you.

Should I Take Centrophenoxine

What Are Some Notable Studies Performed on Centrophenoxine?

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Cited Studies

1. Marcer, D; Hopkins, SM (1977). “The differential effects of meclofenoxate on memory loss in the elderly”. Age and ageing 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662

2. Centrophenoxine Page @ The American Academy of Anti-Aging Medicine

3. http://www.ncbi.nlm.nih.gov/pubmed/18365480

4. Dimpfel W, Wedekind W, Keplinger I (May 2003). “Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states”. Eur. J. Med. Res. 8 (5): 183–91. PMID 12844472.

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